Dennis Hedgecock, PhD
Founder, Chief Science Officer

Professional Preparation

St. Mary’s College, California                          Biology                        B.S. Magna cum Laude 1970

University of California, Davis                       Genetics                       Ph.D. 1974

University of California, Davis             Aquaculture Genetics           Postdoc, 1974-1978


Chief Science Officer, Pacific Hybreed, Inc., 2014-present

Paxson H. Offield Professor in Fisheries Ecology, Department of Biological Sciences, University of Southern California, 2003–present; starting two-year phased retirement August 16, 2017

Geneticist, Department of Animal Science, University of California, Davis and the Bodega Marine Laboratory, Bodega Bay, California, 1990-2003

Associate Geneticist and Lecturer, Agricultural Experiment Station, Aquaculture and Fisheries Program, Department of Animal Science, University of California, Davis and the Bodega Marine Laboratory, Bodega Bay, California, 1983‑1990

Assistant Geneticist and Lecturer, Agricultural Experiment Station, Aquaculture Program, Department of Animal Science, UC, Davis and the Bodega Marine Laboratory, 1978‑1983

Publications (of 135, peer-reviewed publications)

       i. Five Most Relevant

Hedgecock, D. and A. I. Pudovkin.  2011.  Sweepstakes reproductive success in highly fecund marine fish and shellfish: A review and commentary.  (Invited contribution to 60th anniversary issue, on the basis of citations to Hedgecock, 1986, below)  Bulletin of Marine Science 87:971-1002.

Ghiselli, F., L. Milani, P. L. Chang, D. Hedgecock, J. P. Davis, S. V. Nuzhdin, and M. Passamonti. 2012.  De novo assembly of the Manila clam Ruditapes philippinarum transcriptome provides new insights into expression bias, mitochondrial doubly uniparental inheritance and sex determination. Molecular Biology and Evolution 29: 771-786.

Zhang, G. F., and 92 co-authors. 2012. The oyster genome reveals stress adaptation and complexity of shell formation.  Nature 490:49-52.

Hedgecock, D., G. Shin, A.Y. Gracey, D. Van Den Berg and M.P. Samanta. 2015. Second-generation linkage maps for the Pacific oyster Crassostrea gigas reveal errors in assembly of genome scaffolds. G3: Genes Genomes Genetics 5: 2007-2019.

Plough, L.V., G. Shin and D. Hedgecock. 2016. Genetic inviability is a major driver of type III survivorship in experimental families of a highly fecund marine bivalve. Molecular Ecology 25: 895-910.

      ii. Five Additional (most highly cited papers, sorted from highest)

Hedgecock, D.  1994.  Does variance in reproductive success limit effective population sizes of marine organisms?  In: Genetics and Evolution of Aquatic Organisms.  Beaumont, A.R. (editor).  Chapman and Hall, London.  pp. 122-134.

Hedgecock, D.  l986.  Is gene flow from pelagic larval dispersal important in the adaptation and evolution of marine invertebrates?  Bulletin of Marine Science 39:550-564.

Ayala, F. J., M. L. Tracey, D. Hedgecock and R. C. Richmond.  1975.  Genetic differentiation during the speciation process in Drosophila.  Evolution 28:576-592.  (Reprinted In: Genetics of Speciation.  Jameson, D.L. (editor), 1977, Dowden, Hutchinson & Ross, Stroudsburg, PA, pp. 99-115.)

Stoneking, M., D. Hedgecock, R. G. Higuchi, L. Vigilant and H. A. Erlich.  1991.  Population variation of human mitochondrial DNA control region sequences detected by enzymatic amplification and sequence-specific oligonucleotide probes.  American Journal of Human Genetics 48:370-382.

Ayala, F. J., D. Hedgecock, G. S. Zumwalt and J. W. Valentine.  1973.  Genetic variation in Tridacna maxima, an ecological analog of some unsuccessful evolutionary lineages.  Evolution 27:177‑191.

Synergistic Activities

  • Over the past 14 years at USC, Hedgecock has taught in three undergraduate courses, Advanced General Biology: Organismal Biology and Evolution, Evolution and Population Genetics, and Conservation Genetics, and a core course for first-year students in the Graduate Program in Marine Biology and Biological Oceanography, Evolution and Adaptation of Marine Organisms. He has also organized advanced graduate seminars in Population Genetics of Marine Organisms and Food from the Sea.
  • Chair of the Oyster Genome Consortium (70 senior investigators, 12 countries), which successfully petitioned to have BAC libraries made for both the Pacific and Eastern oysters from the National Human Genome Research Institute and to have a large-scale EST sequencing project for the Pacific oyster done by the DOE Joint Genome Institute. The OGC collaborated with the Oyster Genome Project of the Chinese Academy of Sciences, Institute of Oceanology, and the Beijing Genome Institute, which sequenced the genome of a fourth-generation inbred Pacific oyster, supplied by Hedgecock.
  • Co-Chair, National Research Council Committee on Non-native Oysters in the Chesapeake Bay.
  • Member of the Endangered Species Act-mandated, NOAA Fisheries Recovery Team for the endangered Sacramento River Winter Chinook Salmon and Chair of the Genetics Subcommittee for the National Fish & Wildlife Service Winter Chinook Salmon Captive Breeding Program.
  • Member of the Advisory Board for the Molluscan Broodstock Program, a breeding program for the U.S. West Coast oyster farming industry, funded as a USDA Special Project.
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